Archive / Volume LXXVIII 2025

Rostyslav KOSTIUK¹, Yuriy HORAK², Mykola OBUSHAK², Iryna SOBECHKO¹

¹ Lviv Polytechnic National University, St. George's Square 3/4, 79013 Lviv, Ukraine
e-mail: rostyslav.r.kostiuk@lpnu.ua

²Ivan Franko National University of Lviv, Kyryla i Mefodiya St., 6, 79005 Lviv, Ukraine

DOI:

THERMODYNAMIC PARAMETERS OF SOLUBILITY OF 1-R-2-METHYL-5-PHENYL-PYRROLE-3-CARBOXYLIC ACIDS IN ACETONITRILE

The 1-R-2-methyl-5-phenyl-pyrrole-3-carboxylic acids were synthesised by the Paal-Knorr reaction. The enthalpy and entropy of dissolution of acids in acetonitrile were calculated from the experimentally determined temperature dependence of solubility. Taking into consideration the enthalpy and entropy of melting reduced to 298.15 K, the enthalpies and entropies of mixing of the studied pyrrole acids with acetonitrile were calculated. The nature of the interaction between the solvent and the dissolved substances was determined.

Keywords: polysubstituted pyrroles; Paal-Knorr reaction; pyrrole-3-carboxylic acids; enthalpy of dissolution; enthalpy of mixing; enthalpy of melting; acetonitrile.

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